![]() ![]() Antagonism of orexin ( hypocretin) receptors → ↓ wakefulness.Activation of MT1 and MT2 receptors in suprachiasmatic nuclei of the hypothalamus → ↓ sleep-onset latency.Generalized-onset and focal-onset seizures.Intermediate-acting: amobarbital, butalbital Short-term treatment for insomnia or anxiety.Short-acting: pentobarbital, secobarbital GABA A receptor agonism → ↓ neuronal excitability in the brain → ↓ ICP and sedative, hypnotic, and antiepileptic effects.Ultra-short acting: thiopental, methohexital Long-acting: diazepam, chlordiazepoxide, clonazepam, tetrazepam, flurazepam ![]() Intermediate-acting: lorazepam, temazepam, oxazepam, lormetazepam, alprazolam
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